In RevMan5, authors can select analyses from a list of five options:
a simple analysis of a single test;
a simple analysis of a single test that investigates heterogeneity (subgroups);
an analysis comparing several tests;
an analysis comparing several tests that investigates heterogeneity (subgroups);
an analysis of two tests restricted to paired data.
For each analysis paired forest plots of sensitivity and specificity can be created and summary ROC plots produced. In addition, plots of the summary ROC curve, based on the Littenberg and Moses (Littenberg 1993) linear regression model can be presented. However, summary ROC curves, average operating points including 95% confidence intervals and 95% prediction regions can also be produced in RevMan5 using estimates from more valid statistical models: the hierarchical summary ROC (HSROC) model and the bivariate model.